MELATONIN
INTRODUCTION
It
was first confine and classify by American Physician Aaron B.Lerner in 1958 and
his colleagues at Yale University School of Medicine. They gave the substance
its name based on its ability to lighten skin color in frogs by reversing the
skin shade effect of melanocycle stimulating hormones.
BACKGROUND OF MELATONIN
It
was found in animals, plants and microbes Aaron B.Lerner of Yale University is
naming the hormones and also for audible its chemicals structure in 1958 in
mammals, the melatonin was produced by the pineal gland .The pineal gland is
small endocrine gland, its size of a rice grain and shaped like a pine cone, it
is determine in the center of the brain (rostro- dorsal to the superior
colliculus) but outside the blood-brain barrier.
The
deposit of melatonin increasing in shade and decreases during hand out to
light, there by arrange the circadian rhythms of several biological function,
including the sleep-wake cycle. Melatonin improves the sleep –wake cycle by
chemically causing dullness and lowering the body temperature.
DISCOVERY OF MELATONIN
The
melatonin was first affirmation that the pineal gland deposits a biologically
flowing composition now known as melatonin, was establish by the measure of the
pineal tissues selection from coarse sources to alter melanin pigmentation in
frogs, causing melatonin addition, giving upgrade to the name melatonin. In
human melatonin is produced mainly in the pineal glands and small allocation in
the retina. The combination and releases of melatonin are activated by shade
melatonin is the chemical delivery of darkness and check by light. melatonin is
called also mother hormone of chronobiological has been known as an effective
sleeping worker.
MELATONIN IS A HORMONE
It
is a hormone that deposit by the pineal gland of the endocrine system. It is a
small pea-sized gland constitute behind the middle region of the brain. Its
function is to activate our body cell when it’s time to sleep and wake up. The
hormone is deposit in comeback to darkness. Hence the name of hormone darkness
our body produces more melatonin hormone during the nighttime.
The hormonal level normally increases in the evening,
and they drop in the morning as the sun rises. During the daytime the pineal
gland is less active and as the darkness occurs or during the nighttime, the
pineal is active and follow through melatonin which is absolution into the
blood melatonin level in the blood stay bright for about 12hours all through
the night.
FUNCTION OF MELATONIN
The
function of melatonin in our body. Melatonin is a hormone that your brain
aftermath in comeback to darkness. It helps with the double crossing of your
circadian rhythm (24hour internal clock) and with sleep. Being hand out to
light at night can block melatonin production.
1.
Melatonin plays important role in improve
of sleep cycles.
2.
They are arranging the female menstruation
cycle.
3. Melatonin hormone has an expressive follow through in affectingly circadian rhythms and relationship photoperiod.
4. Malatonin has an expressive follow through on reproduction and other phenomena showing circadian rhythm.
5. This hormone helps such ADHD and autism.
6. The hormone acknowledges to be the body
natural pacemakers as its plays a conducive role in distinctive of the day and
time of the year helping to arrange your body internal clock.
USES OF MELATONIN
Melatonin
is use in begrudging weight loss in people who are very ill (cachexia or
wasting syndrome.) Talking melatonin by mouth doesn’t advance fondness, body
weight, or body distribution in people with wasting syndrome from cancer.
Diseases,
such as Alzheimer diseases that interface with thinking (dementia taking
melatonin by mouth does not improve attitude or change symptoms in people with
Alzheimer disease or other form of memory loss, but its ability break abashing
when the sun goes down in people with this condition.
SUN BURN
Applying
melatonin gel to the skin before sun acknowledgment seems, to help anticipate
sun burn. A group of painful condition that change the jaws joint muscle. Taking
melatonin by a mouth at bedtime for 4 weeks break pain in females with jaw
pain.
*Low level of platelets
in the blood.
INSOMNIA
Taking
melatonin by mouth short term, seems to shorten the time it takes to fall
asleep in people with insomnia, but only by about 7 -12 minutes. It not bright
if it changes the amount of time beat up sleeping.
JET LAG
Taking
melatonin by mouth can improve undisturbed symptoms of jet lag such as
alertness, but it ability not be help shorten the time it takes for people with
jet lag to fall asleep.
MIGRAINE
Taking
melatonin by mouth before bed can anticipate t migraines in adults and
children. It’s not bright if melatonin help treat migraines.
A PAINFULL UTERINE DISORDER
(Endometriosis)
pain and pain killer use in adults with this condition. It also breaks pain
menstruation, inter course and which going to the bathroom.
HIGH BLOOD PRESSURE
Taking
the direction –absolution from of melatonin mouth before bedtime seems to the
blood pressure in people with high blood pressure. Immediate release bearing
does not seem to work.
DEPRESSION
Melatonin can make
symptoms of distress worse
SEIZURE DISORDERS
Using melatonin might
increases the handout of having are break down.
TRANSPLANATE
RECIPIENTS
Peoples who have had a displace
regularly take corrective to beatdown the immune system.
BENEFITS OF
MELATONIN
powerful Antioxidant:
melatonin increases the bearing of antioxidant
enzymes in the body that protect the oxidative enzymes accent and abutment
mitochondria function. It also protects join that can agonize mitochondria
function.
Boosts Immunity:
The melatonin support the
immune function and it gives your body the power altercation to against
infection diseases. And it also ability to act a drug in immune suppressive
diseases.
Benefits for heart health:
Melatonin
offers cardio-protective benefits and potent anti-exciting and antioxidant
abilities can help anticipate heart attacks and strokes.
Benefits for lower blood pressure:
The melatonin also helps in lower blood pressure in our body.
melatonin keeps blood pressure under control. Melatonin acts acceptable on different
level of hypertension including organ protection and it is also used as
supporting therapy in patients with hypertension.
Important Eye health:
Melatonin
also supports a healthy vision by abstain the death of cone cell that help in identifying
color. they protect the cell that makes eye pigment.
Improves insulin’s function:
when people high intake of melatonin in night the handout of
developing diabetes. They advance balance and protect insulin producing cell in
the pancreas from death. and also, insulin contention in our body.
SIDE EFFECTS OF MELATONIN
There are
many side effects of melatonin
sleepiness and fatigue:
when people high intake in doses between 3 and 10mg daily they cause
sleepiness and fatigue. When women’s daily intake of melatonin for several
months. they cause in women breast cancer and survivors reported case of sleepiness,
fatigue and cause sleep disorders.
Digestive issues:
when people intake of melatonin in our body. The side effects
are vomiting and digestive issues in our body. When people start taking
melatonin the melatonin can activate the receptors in the gastrointestinal
tracts.
cardiovascular issues:
The
melatonin activates arrhythmias and cardiovascular issues in patient. They also
have case of cadence lasting for several weeks and low blood pressure in
children.
Restless legs syndrome:
The
melatonin can intake causes changeable leg syndrome. the symptoms usually occur
in the night or evening.
Nightmares:
when adult and children intake of melatonin doses between 3 and
5mg in daily they cause nightmares. When people are work up form 4hours after
taking melatonin they cause nightmares.
Irritability and mood changes:
The irritability, and mood changes regular occur in patients.
When people are daily intake of 2.5mg of melatonin for more than a year a
cognitive decline, mood, attitude or and sleep disturbance in elderly people.
Hypothermic effects:
when people daily intake of melatonin in our body they lead to
the lowering of body temperature.
Low level of melatonin hormone in our body
when
melatonin hormone low in our body the symptoms are mood, swings, distress etc.
The main
factors for the decreases in the level of melatonin hormone includes.
1- Age.
2- accent.
3- Lack of sleep.
4-Night
shift work.
5-Excessive
exercises at night.
6-increased
animation by the liver.
7-Intake of
more coffee, tobacco, and alcohol.
High level of melatonin hormone in our body
when
melatonin is high in our body they secreted leads to nausea, seizures, headache,
mood swing, memory, disruption.
The main
factors for the increased in the level of melatonin hormone includes.
1- Extended
nocturnal dark phase.
2-Calcium
and other supplements.
3- acknowledged
to bright light in the morning.
4-
Decreases in the metabolic function of liver.
5-Intake of
more melatonin or tryptophan additional, includes the vitamin, B3, B6, Calcium
etc.
No comments:
Post a Comment